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泵给药短效多激素组合专利申请将Adocia临床研究扩展到肥胖症领域 - TechiLive.in

泵给药短效多激素组合专利申请将Adocia临床研究扩展到肥胖症领域

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里昂, May 26, 2021 (GLOBE NEWSWIRE) — Adocia (巴黎泛欧交易所:FR0011184241 – ADOC),一家处于临床阶段的生物制药公司,专门开发蛋白质和多肽的创新配方,今天宣布,已提交了三项专利申请针对治疗代谢性疾病,包括肥胖症,NASH(非酒精性脂肪性肝炎),2型糖尿病和神经退行性疾病。此三项专利涉及通过泵给药的短效激素组合。胰高血糖素-艾塞那肽(BioChaperone® GluExe)的组合在肥胖小鼠群体中获得的首个临床前结果显示,治疗14天1后,小鼠体重减轻量为25%,而单独使用艾塞那肽减轻量则为15%。目前同样具有良好效能的第二种组合普兰林肽和艾塞那肽(PramExe)正在开发中。所使用的泵均为已经上市的用于胰岛素治疗的泵,尤其是易于使用且适合于此目的的贴片式泵。 使用者可以调整最大耐受剂量,从而优化其获益/风险平衡。

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