348 Unusual Child Hepatitis Cases; Rinvoq Impresses in Crohn’s; ED and Cirrhosis

As of Tuesday, there are 348 probable cases of child hepatitis of unknown origin in 21 countries, with 26 cases requiring liver transplants, the World Health Organization announced.

Is there a link between the Omicron variant and the unknown hepatitis cases? One Japanese researcher says yes. (Japan Times)

In the phase III U-ENDURE study of moderate to severe Crohn’s disease patients who responded to induction upadacitinib (Rinvoq) after failing prior therapies, a year of upadacitinib maintenance led to significantly more remissions versus placebo, drugmaker AbbVie said.

Sun Pharma said the FDA approved its generic form of extended-release mesalamine capsules, an anti-inflammatory used for mild flare-ups in ulcerative colitis.

An endoscopist’s proximal serrated polyp detection rate was inversely associated with the incidence of interval post-colonoscopy colorectal cancer (CRC), a Dutch study found. (Lancet Gastroenterology and Hepatology)

A sample of U.S. pediatric emergency department visits from 2006 to 2018 found that ondansetron use increased “markedly” among kids with acute gastroenteritis (from 10.6% to 59.2%), yet without any corresponding decrease in rates of rehydration or hospitalizations. (JAMA Network Open)

Long-term programmatic CRC screening and surveillance was safe, since most major events such as serious cardiopulmonary events were rare, a Veterans Affairs study found. (Gastrointestinal Endoscopy)

Opioid users who underwent high-resolution manometry had a higher long-term symptom burden and were more likely to have hypercontractile esophagus or distal esophageal spasm versus non-opioid users. (Gastroenterology)

Risk factors for erectile dysfunction in men with cirrhosis included older age, longer duration of cirrhosis, and presence of major depression, a study in India found. (Journal of Clinical and Experimental Hepatology)

  • Zaina Hamza is a staff writer for MedPage Today, covering Gastroenterology and Infectious disease. She is based in Chicago.

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