AI Spots Cognitive Decline; Vax Reactions in MS; When Cutting Opioids Harms Patients

A deep learning model accurately detected cognitive decline from clinical notes up to 4 years before patients were diagnosed with mild cognitive impairment. (JAMA Network Open)

Subjective sleep difficulties were associated with self-perceptions of aging. (Behavioral Sleep Medicine)

Blood biomarkers p-tau181 and p-tau231 were linked to cognitive decline in people with probable dementia with Lewy bodies. (JAMA Neurology)

No significant association between blood pressure reduction and lower risk of cognitive decline, dementia, or mild cognitive impairment emerged in a meta-analysis of clinical trial data. (JAMA Network Open)

Treatment with newly approved avalglucosidase alfa (Nexviazyme) led to improvements in respiratory function, ambulation, and functional endurance in people with late-onset Pompe disease, the phase III COMET study showed. (Lancet Neurology)

The $56,000 price tag for aducanumab (Aduhelm) taps into key features of physician-administered drugs — Medicare’s reimbursement formula, doctors’ pay for infused drugs, and cost-sharing — that may inform drug pricing policy discussions. (New England Journal of Medicine)

People with multiple sclerosis (MS) on certain disease-modifying therapies were less likely to report reactions to SARS-CoV-2 vaccines, but overall, side effects in MS patients were similar to those of the general population. (Neurology Neuroimmunology & Neuroinflammation)

Young veterans with mild traumatic brain injury showed premature cognitive decline, with some results comparable to people with early Parkinson’s disease. (PLOS One)

Activity patterns identified whether slow gait indicated an increased risk of developing mild cognitive impairment or Alzheimer’s disease. (JAMA Network Open)

A woman sued her husband’s physicians after they cut his opioid dose and he killed himself; a jury awarded the family nearly $7 million. STAT looks at the complex decisions that accompany opioid reduction.

The ALS drug riluzole (Rilutek) may decrease disease progression in Niemann-Pick disease, type C1, a mouse study suggested. (Molecular Genetics and Metabolism)

Sagent Pharmaceuticals is recalling four lots of injectable levetiracetam, a drug used to treat seizures, due to a container closure problem that may lead to a non-sterile product, the FDA said.

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

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