ALS-Lipids Link, Eye Disease and Heightened Dementia Risk; Parkinson’s and NSAIDs

Elevated levels of HDL and apolipoprotein A1 were linked to a lower risk of amyotrophic lateral sclerosis (ALS), U.K. Biobank data showed. (Journal of Neurology, Neurosurgery, & Psychiatry)

Also from the U.K. Biobank cohort: age-related macular degeneration, cataracts, and diabetes-related eye disease were tied to a heightened risk of dementia. (British Journal of Ophthalmology)

Amyloid produced in the liver caused neurodegeneration in a mouse study. (PLOS Biology)

Nearly 8% of patients with opioid use disorder died within 12 months of being discharged from a general hospital admission. (Journal of Addiction Medicine)

The FDA announced that Jacobus Pharmaceutical recalled three lots of amifampridine (Ruzurgi) 10 mg tablets, a drug used to treat Lambert-Eaton myasthenic syndrome in children, after lab tests showed they were contaminated with yeast, mold, and aerobic bacteria.

Cumulative high exposure to non-steroidal anti-inflammatory drugs (NSAIDs) was not associated with Parkinson’s disease incidence, a study in Norway showed. (PLOS One)

A transcriptome-wide association study identified 18 genes significantly associated with Parkinson’s. (npj Parkinson’s Disease)

T-cell specificity was tied to disease heterogeneity in multiple sclerosis (MS). (Neurology Neuroimmunology & Neuroinflammation)

Six months after colorectal cancer diagnosis, overall and cancer-specific survival was lower in MS patients than in people without MS. (Neurology)

Axsome Therapeutics said the FDA accepted the new drug application for AXS-07, a meloxicam-rizatriptan combination for acute migraine treatment, with a decision expected in April 2022.

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

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