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Dapagliflozin’s HFpEF Win; Angiograms of the HIV+; Side Effects of PCSK9 Inhibitors?

For heart failure patients with mildly reduced or preserved ejection fraction in the DELIVER trial, dapagliflozin (Farxiga) helped reduce the risk of cardiovascular death and worsening heart failure, AstraZeneca announced, paving the way for a new indication in the future.

But how many real-world heart failure patients would actually be eligible for SGLT2 inhibitors based on trial criteria? (Journal of Cardiac Failure)

A study linking hypertensive disorders of pregnancy with long-term cardiovascular disease suggested a benefit in screening women with a history of preeclampsia or gestational hypertension for several established cardiovascular risk factors. (Journal of the American College of Cardiology)

An urgent call to screen children for familial hypercholesterolemia. (European Heart Journal)

Among Asian American subgroups, women of Indian descent were at highest risk of death from ischemic heart disease, and Indians of both sexes were at highest risk of heart failure deaths, whereas Vietnamese people had the highest odds of mortality from cerebrovascular disease. (Circulation: Cardiovascular Quality and Outcomes)

E-cigarette users who don’t smoke cigarettes did not show an excess of cardiovascular disease in the short term compared with non-smokers. (Circulation)

Survivors of out-of-hospital cardiac arrest had a 10-year survival rate of around 63% across continents, a meta-analysis found. (JAMA Cardiology)

Coronary angiograms of HIV-positive individuals with acute coronary syndrome tended to show more diffuse significant coronary lesions, coronary artery aneurysms, coronary artery ectasia, and more TIMI 3 of the culprit lesion rather than TIMI 0 flow. (Circulation: Cardiovascular Interventions)

In a remote area of Germany, acute ischemic stroke patients reached endovascular therapy quicker when transferred by helicopter instead of driven to a stroke hospital. (JAMA)

Meanwhile, in a non-urban part of Spain, direct transportation to a thrombectomy-capable stroke center or a local stroke hospital resulted in similar functional outcomes for stroke patients with suspected large vessel occlusion. (JAMA)

CathVision said that FDA gave 510(k) clearance to its ECGenius electrophysiology recording system.

A Japanese center’s protocol of left ventricular assist device explantation after myocardial recovery appeared to be safe and associated with good longer-term outcomes in people with dilated cardiomyopathy. (ESC Heart Failure)

A meta-analysis showed that PCSK9 inhibitors were associated with severe injection site reactions, but not cataracts, gastrointestinal hemorrhage, neurocognitive events, new-onset diabetes, or severe myalgia or muscular pain. (Heart)

A cardiologist in Canada is facing mounting charges of sexual assault from former patients, Calgary police announced.

  • Nicole Lou is a reporter for MedPage Today, where she covers cardiology news and other developments in medicine. Follow

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