Is It Necessary to Include Anti-Obesity Medications in Your Weight Loss Program?


The U.S. Food and Drug Administration (FDA) has approved several prescription medications for weight loss and chronic weight management, also called anti-obesity medications. However, they have limited health insurance coverage.

‘Access to anti-obesity medications combined with a multidisciplinary weight management program provides a more effective treatment compared to a weight management program without access to these medications.’


“The research results support the need to treat patients with a multidisciplinary weight management program that incorporates safe and effective medications to lose weight and maintain weight loss,” said Bartolome Burguera, M.D., Ph.D., chair of Cleveland Clinic’s Endocrinology & Metabolism Institute and primary investigator of the study.

“Doctors prescribe medications to treat some of the health consequences associated with obesity, such as hypertension and type 2 diabetes. However, medications for weight loss and chronic weight management are underutilized.”

The Centers for Disease Control and Prevention (CDC) reported that more than 42% of U.S. adults have obesity. In addition to the serious health conditions associated with obesity – such as type 2 diabetes, obstructive sleep apnea, high-blood pressure, heart disease and stroke – the CDC also reported the economic impact of obesity on the U.S. healthcare system.


The estimated medical care costs of the disease in the United States represented $147 billion (in 2008 dollars).

The objective of this study was to determine the effect of combining anti-obesity medications with a multidisciplinary employer-based weight management program.

The one-year, single-center, pragmatic clinical trial was conducted in the real-world setting of a workplace health plan.


Details of the Study

The study included 200 adults with obesity (body mass index of 30 or greater) who were enrolled in the Cleveland Clinic Employee Health Plan between January 2019 and May 2020. As part of the health plan, participants had access to a comprehensive weight management program.

In this real-world setting, eligible participants were randomized 1:1 to either a weight management program with FDA-approved anti-obesity medications or a weight management program alone.


The weight management program was administered through monthly shared medical appointments (SMAs) that offered a multidisciplinary approach, including nutrition education.

The monthly SMA visits focused on adopting a healthier lifestyle and addressed the five components of the weight management program: nutrition, physical activity, appetite control, sleep, and mental health. Due to the COVID-19 pandemic, some of the SMAs were conducted virtually.

The 100 study participants, randomized to the weight management program combined with access to the medications, received their prescriptions at the time of their monthly SMAs, based on recommended clinical practice.


Patients were prescribed one of five FDA-approved medications for chronic weight management – orlistat, lorcaserin, phentermine/topiramate, naltrexone/bupropion, liraglutide 3.0 mg.

The medication selected for each patient was at the discretion of the treating provider, and was determined after a thorough assessment and discussion with the participants. (Lorcaserin was withdrawn from the market in February 2020.

The eight patients taking lorcaserin at the time were notified immediately and either switched medications or discontinued medication due to proximity to the end of the study.)


Results of the Study

Research results showed that the participants who had access to the anti-obesity medications averaged significantly greater weight loss at 12 months (-7.7%), compared to the participants who were in the weight management program alone (-4.2%).

In the group who had access to the medications, 62.5% of the participants lost at least 5% of their weight, compared to 44.8% of the participants in the group with the weight management program alone. SMA attendance was higher among the participants who had access to the weight loss medications.


“Many patients see improvement in their health when they lose 5% of their weight,” said Kevin M. Pantalone, D.O., first author of the study and an endocrinologist at Cleveland Clinic. “Based on our study results, access to anti-obesity medications combined with a multidisciplinary weight management program provides a more effective treatment compared to a weight management program without access to these medications.”

More long-term research is needed in real-world, employer-based settings to evaluate the costs and benefits of anti-obesity medications and their use in conjunction with workplace wellness plans.

Source: Eurekalert


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