Parental T1D Impacts Kids; Extracellular Vesicles; Tirzepatide Cuts Liver Fat

A nationwide study of Danish children found that offspring of parents with type 1 diabetes scored lower on school tests. (PLOS Medicine)

The Endocrine Society spoke out against the Florida Department of Health’s bulletin on gender-affirming care for transgender and gender-diverse youth, calling for it to be rescinded.

In other news, the Endocrine Society also released a new Scientific Statement highlighting how extracellular vesicles are important for understanding certain endocrine disorders, especially when developing new treatments. “We hope this statement brings awareness to the significance of extracellular vesicles in endocrinology and encourages more research on their potential as biomarkers and therapeutics,” said Carlos Salomon, PhD, DMedSc, of the University of Queensland in Australia. (Endocrine Reviews)

Black patients with diabetic foot ulcers — particularly those living in rural areas — had a much higher rate of major leg amputation and death. (JAMA Network Open)

A substudy of the SURPASS-3 trial found that treatment with the investigational GIP/GLP-1 receptor agonist tirzepatide significantly reduced liver fat, visceral fat, and abdominal fat compared with insulin degludec in people with type 2 diabetes. (The Lancet Diabetes & Endocrinology)

A meta-analysis of rodent studies linked PFAS exposure to liver injury, including high alanine aminotransferase levels and steatosis. (Environmental Health Perspectives)

In a three-part review published in Biochemical Pharmacology, researchers highlighted causal links between environmental chemicals found in everyday objects and obesity.

A routine second fine needle aspiration biopsy for thyroid nodules probably isn’t necessary due to the low false-negative rate of the initial biopsy. (BMC Endocrine Disorders)