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Personalizing treatment for severe limb injuries

A team of scientists, led by Scott Frey at the University of Missouri, have developed an innovative technique using small wearable sensors to gather data on how people — who have suffered from a traumatic hand amputation — use a prothesis versus a transplanted hand in everyday life. So far, the data shows people with a transplanted hand demonstrate a more balanced use of their hands than those who use a prothesis.

Frey is the Miller Family Chair in Cognitive Neuroscience in the Department of Psychological Sciences, and also has a joint appointment in the Department of Physical Medicine and Rehabilitation.

“Most activities performed by a typical adult involve a fairly evenly balanced reliance on both hands,” Frey said. “Over the course of a normal day, roughly 55% of people’s activities involve the dominant hand and 45% involve the non-dominant hand. Now we have evidence that shows experienced prosthesis users rely on their prosthetic hand during about 20% of daily activities and use their uninjured limb for the remaining 80%. Hand transplant recipients exhibit a more balanced pattern of limb use that is closer to what we see in healthy adults, although not quite at the 55%/45% split.”

Nevertheless, Frey also noted that a hand transplant comes with significant risks, such as developing certain infections and cancers from the lifetime use of immunosuppressants needed to help keep the body from rejecting the new hand.

Frey said the findings from this study could help physicians and other medical professionals personalize treatment options to meet a patient’s individual needs based on their daily routine.

“We can bring people into a clinic or laboratory setting, and measure how they are doing with a prosthetic or hand transplant, but these observations are typically made under optimal and artificial conditions, and therefore might not accurately show us how people are truly functioning during their everyday lives,” Frey said. “These sensors, which continuously record movements over multiple days while people go about their lives, have the ability to revolutionize treatments by providing real world data that will help us develop personalized approaches to treat traumatic hand loss.”

While military personnel can experience a traumatic hand loss in both combat and non-combat situations, Frey said these injuries can also occur in civilian populations with work-related or recreational accidents, such as with farming equipment or fireworks. The study collected data continuously over three days as participants went about their normal lives. They wore four different sensors — two on the wrists of the prosthetic or transplanted hand as well as on the uninjured limb, and one on each the upper arms.

Frey said their technique could also lead to new ways for medical professionals to evaluate the effectiveness of treatments and personalized care for a variety of neurological diseases that affect hand use, including multiple sclerosis and stroke. Frey’s own mother had multiple sclerosis, and watching her condition deteriorate continues to motivate his work into furthering knowledge of the neural mechanisms and cognitive processes that are responsible for complex behaviors.

In addition to possible applications in other areas of medicine, including neurology, Frey’s approach is currently being used to investigate patterns of recovery in individuals with severe upper limb injuries who are at increased risk of developing chronic one-handedness through learned disuse of the injured limb. That project, scheduled to be completed in fall 2024, is being supported by a $1.5 million grant from the United States Department of Defense Restoring Warfighters with Neuromusculoskeletal Injuries Research Award, and includes collaborators from the schools of medicine at Johns Hopkins University, Ohio State University and Washington University in St. Louis.

Funding was provided by a grant from the Department of Defense (MR140043). Co-authors include Binal Motawar, Kelli Buchanan, Carmen Cirstea and Sean Morrow at MU; Christina Kaufman at University of Louisville; and Phil Stevens at Hanger Clinic in Salt Lake City, Utah.

Story Source:

Materials provided by University of Missouri-Columbia. Note: Content may be edited for style and length.

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